#Chimex loreal skin#

Photosensitivity reactions and photodermatoses are mostly mediated by UVA ( 9, 10).įor all these reasons, it is evident that sunscreens must contain UVA filters in association with UVB ones. There is also serious concern about UVA contribution in the development of malignant melanoma and squamous tumors ( 7, 8). ROS cause damage to DNA, cells, vessels and tissues ( 1- 6). UVA mainly produces reactive oxygen species (ROS) through interaction with endogenous and exogenous photosensitizers.

#Chimex loreal skin#

However, there is now increasing evidence that UVA wavelengths (320–400 nm) that penetrate deeper into the skin cause a wide variety of biological effects. The UVB range of the sun spectrum (290–320 nm) is generally thought to be the most deleterious radiation of sunlight that impacts skin at the earth level. Human exposure to ultraviolet (UV) radiation from sunlight can cause many adverse effects such as sunburn, pigmentation, immunosuppression, photodermatoses, photoaging and skin cancer. Finally PMLE study demonstrated that UVA protection was essential for the prevention of this photodermatose.Ĭonclusion: Mexoryl ® SX formulated in sunscreens or daily use products have been shown to be an effective UV absorber, leading to an increased efficacy of these products against a large number of biological damage induced by UVA, SSR or sun exposure.

It also reduced the enhancement of collagenase 2 mRNA expression induced by SSR exposure. Mexoryl ® SX formulations also prevented or significantly decreased to minimal, ferritin, tenascin and lysozyme expression induced by repeated UVA or SSR exposure. In the studies looking at the suppression of DTH reactions to recall antigens by the different UV spectra, the LC alterations and the cis UCA formation, Mexoryl ® SX formulations always showed a higher protective potency than sunscreen without it even when the protection against erythema was similar (products with same SPF). Pyrimidine dimer formation and p53 accumulation were significantly reduced by formulations with Mexoryl ® SX. For a same sun protection factor (SPF) the higher the UVA protection was, the higher was the PPF. Results: Mexoryl ® SX-containing formulations showed a dose-dependent level of protection against pigmentation. Prevention of the polymorphous light eruption (PMLE) in patients prone to develop this disease. Reduction of epidermal and dermal alterations induced by repeated UVA or UV solar simulated radiation (SSR) using histology or immunohistology. Protection of immune system using delayed type hypersensitivity (DTH) reactions to recall antigens, isomerization of urocanic acid (UCA), alteration of Langerhans cells (LC) density, morphology and function. Prevention of excessive pigmentation induced by UV exposure in Caucasian and Asian skins using a method that measures pigmentation protection factors (PPF).Įfficacy against DNA damage by measurement of pyrimidine dimer formation and p53 protein accumulation. Methods: The following assessments were conducted:

As a consequence, to provide adequate protection, sunscreens or skin care products for daily use protective products need UVA absorbers combined with UVB ones.Īim: To assess the efficacy of sunscreens containing a broad-spectrum UVA absorber the Mexoryl ® SX or ecamsule and to compare formulations with and without it through a large number of clinical studies in human volunteers and patients. Moreover UVA is implicated in the etiology of several photodermatoses.

It alters immune function, pigmentation and it is certainly responsible for a large part of photoaging changes. Background: UVA exposure of human skin mainly produces reactive oxygen species (ROS) leading to DNA, cell and tissue damage.